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Car Trips
Lee County lies on the southwest coast of Florida and is easily reached via major interstate highways.
Interstate Travel
Interstate 10 runs east-west from California to Jacksonville, FL, and Interstate 95 extends from the northeastern U.S. to south Florida. Travelers using I-95 can take Interstate 4 west to connect with southbound Interstate 75. North-south I-75 connects directly to I-10 and is the major highway that traverses Lee County, the home of The Beaches of Fort Myers & Sanibel. I-75 begins in south Florida and ends in the Midwestern U.S.
In-Town Driving
In addition to Interstate 75, major roads that convey motorists in Lee County include U.S. 41, which runs north-south and parallel to the interstate; McGregor Boulevard, which extends from downtown Fort Myers and links with roads leading to Sanibel and Captiva islands and Fort Myers Beach; and State Road 78, which connects the mainland with Pine Island, crossing Cape Coral as it extends south and west.
Tolls
Cape Coral Parkway and Midpoint Memorial bridges have a $1 fee going both ways. The bridge that takes U.S. 41 across the Caloosahatchee River is free. The Sanibel Causeway toll is $6, but is charged only for going to Sanibel Island.
Driving Times and Distances
| Distances to Lee County from Cities in Florida: | ||
| City | Miles/Kilometers | Drive Time |
| Daytona | 251 miles/403.9 km | 4 1/4 hours |
| Jacksonville | 335 miles/539.1 km | 5 1/4 hours |
| Miami | 158 miles/254.3 km | 2 1/2 hours |
| Orlando | 196 miles/315.4 km | 3 1/2 hours |
| Tampa | 126 miles/202.8 km | 2 1/2 hours |
| Distances to Lee County from Cities outside Florida: | ||
| City | Miles/Kilometers | Drive Time |
| Boston | 1,478 miles/2,379 km | 23 1/2 hours |
| Chicago | 1,290 miles/2,076 km | 20 hours |
| Cincinnati | 1,043 miles/1,679 km | 16 hours |
| Cleveland | 1,215 miles/1,955 km | 18 3/4 hours |
| Detroit | 1,298 miles/2,089 km | 20 hours |
| Indianapolis | 1,109 miles/1,785 km | 17 hours |
| Milwaukee | 1,389 miles/2,235 km | 21 3/4 hours |
| Minneapolis/St. Paul | 1,704 miles/2,742 km | 26 1/4 hours |
| New York | 1,264 miles/2,034 km | 19 3/4 hours |
| Philadelphia | 1,174 miles/1,889 km | 18 1/2 hours |
| St. Louis | 1,129 miles/1,817 km | 17 1/4 hours |
| Washington, D.C. | 1,029 miles/1,656 km | 15 3/4 hours |
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